氨基酸螯合鐵(Iron amino acid chelate)對(duì)動(dòng)物吸收的影響

大量研究表明動(dòng)物機(jī)體對(duì)甘氨酸螯合鐵有更好的生物利用率，而甘氨酸螯合鐵較好的生物學(xué)效價(jià)可能與其在動(dòng)物機(jī)體內(nèi)的吸收機(jī)制有關(guān)。動(dòng)物機(jī)體吸收外源鐵主要發(fā)生在十二指腸和空腸上段，并需要相關(guān)膜轉(zhuǎn)運(yùn)蛋白的協(xié)助。二價(jià)金屬離子轉(zhuǎn)運(yùn)蛋白 (Divalent Metal Transporter 1，DMT1) 可將腸道內(nèi)包括Fe²⁺ 在內(nèi)的二價(jià)金屬離子轉(zhuǎn)運(yùn)到細(xì)胞內(nèi)，其主要分布在動(dòng)物十二指腸絨毛刷狀緣及隱窩等處，其表達(dá)變化主要由感知體內(nèi)鐵儲(chǔ)存的反饋機(jī)制來調(diào)控；基底膜鐵轉(zhuǎn)運(yùn)蛋白 (Ferroportin 1，Fpn1) 主要負(fù)責(zé)將細(xì)胞內(nèi)的鐵轉(zhuǎn)運(yùn)到血液中。植酸和纖維素等抗?fàn)I養(yǎng)因子能夠與腸道中的亞鐵離子反應(yīng)，形成不溶性復(fù)合物，從而影響鐵離子在腸道內(nèi)的吸收；氨基酸螯合鐵中的鐵元素因?yàn)楹桶被崤潴w的螯合作用，可以避免植酸和纖維素等因素的影響，從而獲得更好地吸收效果；在 Caco-2 細(xì)胞模型上，抗壞血酸鐵和氨基酸螯合鐵具有相似的鐵吸收機(jī)制，均是以鐵離子的形式通過細(xì)胞中的 DMT1 吸收的。

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賴氨酸甘氨酸鎂Magnesium Lysinate Glycinate、甘氨酸谷氨酰胺鎂Magnesium Glycinate Glutamine、檸檬酸蘋果酸鎂Magnesium Citrate Malate、檸檬酸鍶Strontium Citrate、檸檬酸錳Manganese Citrate、檸檬酸銅Copper Citrate、天門冬氨酸鋰Lithium Aspartate、牛磺酸硒Selenium Taurate、抗壞血酸錳Manganese Ascorbate、抗壞血酸亞鐵Ferrous Ascorbate

Effects of Iron amino acid chelate on animal absorption

Many studies have shown that animals have better bioavailability of iron glycine chelate, and the better biological titer of iron glycine chelate may be related to the absorption mechanism in animals. The absorption of exogenous iron mainly occurs in the duodenum and upper jejunum, and requires the assistance of related membrane transporters. Divalent Metal Transporter 1 (DMT1) can transport intestinal divalent metal ions, including Fe²⁺, into cells, mainly at brush margins and crypts of duodenal villi. The change of its expression is mainly regulated by the feedback mechanism of sensing iron storage in vivo. Ferroportin 1 (Fpn1) is responsible for transporting iron from cells into the blood. Phytic acid, cellulose and other anti-nutrient factors can react with ferrous ions in the intestine to form insoluble complexes, thus affecting the absorption of iron ions in the intestine. The iron element in amino acid chelate iron can avoid the influence of phytic acid and cellulose because of chelating with amino acid ligand, so as to obtain better absorption effect. In the Caco-2 cell model, iron ascorbate and iron amino acid chelate have similar iron absorption mechanisms, both of which are absorbed by DMT1 in the cell in the form of iron ion.

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Magnesium Lysinate Glycinate, Magnesium Glycinate Glutamine, Magnesium Citrate Malate, Strontium citrate Citrate, Manganese Citrate, Copper Citrate, Lithium Aspartate, Selenium Taurate, Manganese ascorbate Ferrous Ascorbate Ascorbate.